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Daily pill from Eli Lilly leads to 15% weight loss in midstage study, rivaling Wegovy results without the shot

Published Wed, 05 Mar 2025 02:53:51 GMT

(CNN) — Eli Lilly’s experimental pill for weight loss helped people lose an average of 15% of their body weight after 36 weeks on the highest dose in a midstage trial, rivaling what’s seen with currently approved injectable therapies like Wegovy over longer durations.The drug, orforglipron, had similar side effects as others in the class, known as GLP-1 receptor agonists: primarily gastrointestinal events like nausea, constipation and vomiting, researchers reported in a study published Friday in the New England Journal of Medicine. Results from the Lilly-funded trial were also presented at the American Diabetes Association conference in San Diego.Currently approved medicines for weight loss like Novo Nordisk’s Wegovy are given as once-weekly injections. Novo Nordisk’s Ozempic, which contains the same key ingredient as Wegovy, called semaglutide, and Lilly’s Mounjaro are both approved for Type 2 diabetes but used off-label for weight loss. Orforglipron is part of a new...

Jordan Westburg’s time arrives as Orioles promote No. 4 prospect to majors

Published Wed, 05 Mar 2025 02:53:51 GMT

Orioles executive vice president and general manager Mike Elias often speaks of his desire to see prospects “graduate Triple-A” in terms of performance before promoting them to the majors. Jordan Westburg’s cap and gown at last came Monday.After more than a year of strong performances with Triple-A Norfolk, the Orioles called up Westburg, a 24-year-old infielder Baseball America ranks as the No. 4 prospect in the organization and No. 46 in the sport, before Monday night’s game against the Cincinnati Reds. To create roster space for Westburg, the Orioles optioned infielder Joey Ortiz to Norfolk, while catcher José Godoy cleared waivers and accepted an assignment to Norfolk, opening a 40-man roster spot.In 158 games with the Tides across the past two seasons, Westburg hit .283/.366/.533 with 36 home runs and 128 runs driven in. Promoted to Norfolk alongside eventual top overall prospect Gunnar Henderson early last June, Westburg had to wait much longer for...

Colorado Springs LGBTQ+ club shooting suspect pleads guilty to murder, no contest to hate crime charges

Published Wed, 05 Mar 2025 02:53:51 GMT

COLORADO SPRINGS — A 23-year-old suspect pleaded guilty Monday to carrying out a mass shooting at a Colorado Springs LGBTQ nightclub last year that killed five people and injured 22 others.Anderson Aldrich pleaded guilty in the Nov. 19 attack at Club Q during his arraignment in El Paso County District Court on Monday. Aldrich pleaded guilty to five counts of first-degree murder and 46 counts of attempted first-degree murder.Aldrich also pleaded no contest to two counts of bias-motivated crime, acknowledging that prosecutors likely could prove Aldrich acted at least in part because Club Q was an LGBTQ bar and was patronized by people who identify as LGBTQ.Aldrich will be sentenced to five consecutive life terms.The 23-year-old originally was charged with more than 300 counts in connection with the massacre, including first-degree murder, attempted murder, assault and bias-motivated crimes.Video surveillance footage played in court showed that Aldrich donned body armor and attac...

Ensure Line 5 keeps running until reroute completed in 2026, Enbridge asks U.S. judge

Published Wed, 05 Mar 2025 02:53:51 GMT

WASHINGTON — The company that operates Line 5 is asking a U.S. judge for a measure of certainty that its controversial cross-border pipeline won’t be shut down before it can be rerouted around an Indigenous band’s territory in Wisconsin. Calgary-based Enbridge Inc. wants district court Judge William Conley to clarify his earlier order that the pipeline be removed within three years from land that belongs to the Bad River Band of the Lake Superior Chippewa.New court documents filed Friday, described as “requests for clarification,” stop short of formally asking Conley to stay any shutdown orders until after Enbridge has completed efforts to detour Line 5 around band territory. But they do argue that the company has made a valid argument that the pipeline should be allowed to continue operating, with Bad River receiving a share of the profits, until the reroute is finished. “Enbridge respectfully maintains it has presented legal authority to delay any inj...

Spain announces new department to study effects of very hot weather on health

Published Wed, 05 Mar 2025 02:53:51 GMT

MADRID (AP) — Spain sweltered in its first official heat wave of the year on Monday as the government announced a new department to investigate and alleviate the effects of extreme temperatures on human health.The state weather agency, AEMET, said temperatures were predicted to hit 44 degrees Celsius (111 degrees Fahrenheit) in the country’s south during the hot spell, expected to last until Thursday, and noted that heat waves have become more common during the month of June over the last 12 years.Ecological Transition Minister Teresa Ribera said the country’s rising temperatures put vulnerable populations at risk, and more work is needed to understand how to prepare for longer, hotter summers. “We must investigate what happens to our bodies in response to the effects of climate change, in order to mitigate the consequences on our health,” Ribera said.The proposal to create the new department, called the Observatory for Health and Climate Change, will be presented to SpainR...

Police have questioned person of interest in shooting that killed 3 in Kansas City

Published Wed, 05 Mar 2025 02:53:51 GMT

KANSAS CITY, Mo. (AP) — A person of interest has been questioned in a weekend shooting that killed three people and wounded several more in Kansas City, police said. Responding officers found two men and a woman dead from gunshot wounds at around 4:30 a.m. Sunday in a parking lot where a crowd had gathered, near an auto shop known to host informal after-hours get-togethers, police said. At least five others thought to be wounded there were taken by private vehicles and ambulances to various hospitals, police said. Police said Sunday that another person was wounded in a separate shooting blocks away at about 3 a.m. No additional information in that shooting has been released.Homicide detectives identified a person of interest in the shooting near the auto shop and took a man into custody in Grandview, Missouri, just after 5 p.m. Sunday, according to Officer Jacob Becchina, a police spokesperson. The man’s name was not released, and no charges were reported by Monday morning.Kan...

DeSantis unveils an aggressive immigration and border security policy that largely mirrors Trump’s

Published Wed, 05 Mar 2025 02:53:51 GMT

EAGLE PASS, Texas (AP) — Republican presidential candidate Ron DeSantis promised to end birthright citizenship, finish building the southern border wall and send U.S. forces into Mexico to combat drug cartels as part of an aggressive — and familiar — immigration policy proposal he laid out Monday in a Texas border city.The sweeping immigration plan is the Florida governor’s first detailed policy release as a 2024 contender and represents a long-established wish list of Republican immigration proposals that largely mirrors former President Donald Trump’s policies. Much of DeSantis’ plan faces tall odds, requiring the reversal of legal precedents, approval from other countries or even an amendment to the U.S. Constitution. Still, DeSantis projected confidence on Monday as he slapped at Democrats and Republicans in announcing his new plan, which he detailed further in Eagle Pass, Texas, a community of about 30,000 people set along the U.S.-Mexico border.“For decades, ...

Supreme Court dismisses case in which Democratic lawmakers sued over Trump hotel lease

Published Wed, 05 Mar 2025 02:53:51 GMT

WASHINGTON (AP) — The Supreme Court on Monday dismissed a case it had planned to hear about limits on lawsuits filed by members of Congress against the federal government, in a dispute that involved the former Trump International Hotel in Washington.The justices threw out a federal appeals court ruling that had allowed a lawsuit by Democratic members of the House Oversight Committee to continue. The court’s decision Monday had been sought by the Biden Justice Department, which had worried that the appeals court ruling, if let stand, could lead to a flood of lawsuits from individual members of Congress against the administration.The had lawmakers filed their complaint in 2017 over the Trump administration’s refusal to turn over information about the Trump Organization’s lease of the hotel on Pennsylvania Avenue, between the White House and the Capitol.The high court’s action was prompted by the decision of the Democratic lawmakers, earlier in June, to voluntar...

Conservative Mitsotakis sworn in as Greece’s prime minister while far-right sees election surge

Published Wed, 05 Mar 2025 02:53:51 GMT

ATHENS, Greece (AP) — Center-right leader Kyriakos Mitsotakis was formally sworn in as Greece’s prime minister Monday after easily winning a second term with a record-high margin over the left-wing opposition but also facing a Parliament that includes lawmakers from new far-right parties.With 99.7% of the vote counted, Mitsotakis’ New Democracy party had 40.55% — more than twice the main opposition Syriza party’s 17.84%. It was the largest margin of victory in a Greek election in a half-century and slightly expanded New Democracy’s 20-percentage-point lead in an election held five weeks earlier.Mitsotakis, 55, was sworn in after Greek President Katerina Sakellaropoulou formally gave him the mandate to govern.“My aim was to secure a stable government with a parliamentary majority. Unfortunately, two elections were needed for that,” he said in a televised meeting with Sakellaropoulou, who as head of state holds a mainly ceremonial role.“I have...

S&P/TSX composite up more than 100 points, U.S. stock markets lower

Published Wed, 05 Mar 2025 02:53:51 GMT

TORONTO — Strength in energy stocks helped Canada’s main stock index gain more than 100 points in late-morning trading, while U.S. stock markets were in the red.The S&P/TSX composite index was up 140.19 points at 19,558.42.In New York, the Dow Jones industrial average was down 52.42 points at 33,675.01. The S&P 500 index was down 7.22 points at 4,341.11, while the Nasdaq composite was down 44.37 points at 13,448.15.The Canadian dollar traded for 76.00 cents US compared with 75.76 cents US on Friday.The August crude contract was up 12 cents at US$69.28 per barrel and the August natural gas contract was up three cents at US$2.87 per mmBTU.The August gold contract was up US$5.50 at US$1,935.10 an ounce and the September copper contract was down two cents at US$3.80 a pound.This report by The Canadian Press was first published June 26, 2023.Companies in this story: (TSX:GSPTSE, TSX:CADUSD=X)The Canadian Press